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  • Resident Evil: Requiem Walkthrough Part 1: Full Game Start Guide

Resident Evil: Requiem Walkthrough Part 1: Full Game Start Guide

Complete Resident Evil 9 (Requiem) Part 1 Walkthrough. Features 4K 60FPS PS5 Pro gameplay video embedded from YouTube by MKIceAndFire. Includes our original text guide for puzzles, collectibles, and bosses. Updated Feb 27, 2026.
Published: February 27, 2026 | Updated: February 28, 2026

⚠️Content Warning: While the screenshots in this guide are safe, the embedded YouTube gameplay video contains violence, gore, and horror themes typical of the Resident Evil series. Viewer discretion is advised for the video content.

It’s finally here! Resident Evil 9: Requiem is officially out. Ready to dive in? We’re featuring the ultimate Part 1 walkthrough from MKIceAndFire—the go to channel for high-quality, no-commentary gameplay.

Note: For Part 2 of the walkthrough, please read our guide here: [Click to View]

Play
Video sourced from the MKIceAndFire YouTube channel. (Game content © 2026 Capcom Co., Ltd.)

Support the original creator: Visit MKIceAndFire’s YouTube Channel for more high quality gameplay.

Since the video is over 4 hours long, we’ve skipped the plot summary and focused strictly on marking the locations of key collectibles and items for your convenience.

Note: Clicking the timestamps will take you directly to the scene on YouTube (you will be redirected to the YouTube site).

Here are the key details we’ve compiled

Grace’s Perspective:

Grace reading a note saying "Let's talk Room 204" in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.
Used for editorial and informational purposes only.

11:50 After entering the building, head to the room with the bar. Look for a photo of Grace on the pillar above the counter. Inspect the photo and flip it over to reveal a clue for Room 204 along with a Key.

Use this key to unlock the door on the right side of the bar.

Grace examining The Wrenwood Hotel Floor Plan map on the wall
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

15:25 You’ll pick up a Map here. This is essential, as it reveals your current location and layout, making navigation much easier for the rest of the game.

Wire Cutters tool item showcase in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

17:00 Grab the Wire Cutters here, you’ll need them shortly.

Grace using Wire Cutters to cut wire binding on double doors
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

17:19 Use the Wire Cutters right here to snip the wire blocking the main gate.

Empty Bottle item description and stats in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

45:10 After leaving the blood extraction room, Grace proceeds down the hallway into a dark, lab-like room. Listen for the sound of rolling bottles; you can pick up an Empty Bottle from the floor.

Cherub Key ornate silver key item showcase in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

46:40 The elevator requires a Fuse, which you don’t have yet. Look to the left and open the drawer to find a Key with a Cherub on it.

Grace using the Cherub Key to unlock Room 201 door with cherub carving
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

46:53 Return to the hallway and enter Room 201 (the door marked with three cherubs) using the key you just found. This room serves as a Safe House, featuring a typewriter for saving and various collectibles.

Ornate metal Lighter item used to see in the dark in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

On the shelf in the room to the left of the bed, you’ll find a Lighter.

Fuse Box puzzle requiring a tool to open in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

There is a Fuse on the wall next to the shelf, but you’ll need a tool to remove the screws.

Grace reading Note on Cardboard Box revealing Screwdriver location in Nurses' Station
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

49:06 After leaving Room 201, head to the other room with the toys. Inside the closet, you’ll find a note revealing that the Screwdriver is located in the toolbox at the Nurses’ Station.

Grace finding the Screwdriver inside a toolbox mounted on the wall
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

52:21 Head to the Nurses’ Station. On top of the shelf unit (look for the three orange lights), you’ll find a Toolbox. Open it to get the Screwdriver.

Now that you have the tool, head back to Room 201 (the door marked with cherubs). Use the Screwdriver to remove the screws and retrieve the Fuse. Then, take the Fuse to the elevator and install it.

Grace examining the West Wing Map of Rhodes Hill Chronic Care Center on the wall
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:19:16 After Grace and Leon part ways, Grace must find a way to escape on her own. You can find the West Wing Map here.

Unicorn Trinket Box puzzle solution yielding the Red Jewel in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:20:57
In the Chairman’s Office, you’ll find a Box. Inspect and open it to retrieve the Red Jewel.

In the other room of the office, you can find a Pencil.

Moon Sun Star Moon symbol puzzle lock opening a secret compartment
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:23:05 The safe in the Chairman’s Office requires a specific combination. Please refer to the image above for the code. Inside, you’ll find the Moon Quartz(the first one).

Grace using a key to unlock an ornate door with unicorn carving in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:24:05 How to use the Red Jewel: Head to the Main Hall on the first floor. Enter the room marked with a Unicorn symbol.

This room contains various rewards, but accessing them requires spending your collected Coins.

Also in this room: Pick up the severed hand from the floor and inspect it to find the East Wing Keycard.

Blood Collector analysis device item showcase in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:37:16 In this laboratory, Grace can obtain the Blood Collector.

Grace examining the East Wing Map of Rhodes Hill Chronic Care Center on the wall
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:42:50 When you reach the upper floor, don’t enter the door just yet. First, make sure to pick up the East Wing Map.

ID Wristband Level 1 clearance item in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:45:37 At the end of this hallway, you can obtain the Level 1 Wristband, but be prepared to encounter a “little cutie” along the way.

Use this Wristband to unlock security gates that were previously inaccessible.

Wrench tool for turning hexagonal nuts and bolts in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:50:18 You can find a Wrench in this Safe Room. Be sure to pick it up, as you’ll need it for a later task.

Grace approaching a locked metal door in a dark brick corridor in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

2:06:11 Remember this broken wheel? Use the Wrench here to open the door.

This door leads to the Freezer Room. Grab the Artificial Heart inside, then head to the Laboratory to install it on the corpse.

Grace finding Bar & Lounge Safe with code Left 10 Right 80 Left 30 in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

1:59:28 Bar Safe Code: 10 – 80 – 30. (Turn Left to 10, Right to 80, Left to 30). Inside the safe, you can collect 3 Coins.

Grace collecting Corrosive acid bottle from lab counter in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

2:16:00 You can find the Corrosive on the table. Use it to melt locks that you can’t open otherwise.

Grace solving Sun Quartz puzzle by setting symbols to Star Sun Moon Sun in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

2:20:11 After the cutscene with Victor, return to this room. Use the Corrosive here to break the lock, then open the safe to obtain the Sun Quartz (the second one).

Circuit board puzzle solution with switch positions 1-5 and HAND/AUTO dial in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

The safe also contains a Note with instructions for the Cooler Box in the Underground Garage. Inside the box, you’ll find the Artificial Lungs.

Return to the Laboratory where you installed the heart. Install the Lungs on the corpse. The body will reanimate and attack—defeat it to obtain the Level 2 Wristband, which unlocks even more doors(For example: the Isolation Ward).

Grace finding Examination Room Safe with code Right 30 Left 10 Right 50 in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

Don’t leave just yet! There’s another Safe here. The code is 30 – 10 – 50. Open it to find 3 Coins.

Grace viewing Level 3 ID Wristband and a notebook with star and moon symbol codes in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

With the Level 2 Wristband, enter the Isolation Ward. Inside the Security Manager’s Office, grab the Level 3 Wristband and note down the Symbol Codes(don’t worry if you miss them, though!).

After the cutscene, Grace arrives at the hospital’s Underground Facility. The terrain here is complex and extremely dark, so expect this section to take some time.

Hand-drawn map note explaining how to unlock cells by inserting three joint plugs in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

To restore power to the underground facility, you need to find three Joint Plugs.

  • Plug #1: 3:14:00
  • Plug #2: 3:22:57
  • Plug #3: 3:39:59
Square Socket Wrench tool item showcase in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

3:19:00 You can find the Square Socket Wrench in the Boiler Room.

Map showing Boiler Room location marked with warning sign in Resident Evil Requiem basement
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

Use the Square Socket Wrench here. It can also be used to unscrew the vents to access new areas.

Grace finding Basement Safe with code Right 60 Left 40 Right 80 in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

3:23:05 Found while playing as Leon. Simply open it using the code: 60 – 40 – 80.

Once you have collected all three plugs, return to the control panel at 3:47:34. Insert them to restore power to the cells, then escape with Emily.

After the cutscene, you will obtain the Star Quartz (the third one).

Grace carrying Emily towards the exit door after completing the hospital escape in Resident Evil Requiem
Screenshot from MKIceAndFire’s YouTube video. Game content © 2026 Capcom Co., Ltd.

Head directly to the Main Hall. Insert all three Quartzes to unlock the Exit Door.

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